Plasmodium falciparum is the most deadly human malarial parasite, responsible for an estimated 207 million cases of disease and 627,000 deaths in 2012. Recent studies reveal that the parasite actively regulates a large fraction of its genes throughout its replicative cycle inside human red blood cells and that epigenetics plays an important role in this precise gene regulation. Here, we discuss recent advances in our understanding of three aspects of epigenetic regulation in P. falciparum: changes in histone modifications, nucleosome occupancy (...) and the three‐dimensional genome structure. We compare these three aspects of the P. falciparum epigenome to those of other eukaryotes, and show that large‐scale compartmentalization is particularly important in determining histone decomposition and gene regulation in P. falciparum. We conclude by presenting a gene regulation model for P. falciparum that combines the described epigenetic factors, and by discussing the implications of this model for the future of malaria research. (shrink)

Conscious Agency is a major driver of evolution. Artificial Selection (i.e. Conscious Selection by human breeders) was the foil against which Charles Darwin defined Natural Selection. In later work, he extended Artificial Selection to other species. That ability for social (e.g. sexual) selection must have evolved. Jablonka and Ginsburg identify markers of conscious agency, such as Unlimited Associative Learning (UAL), and show that it must have existed at the time of the Cambrian Explosion. To their insights, my commentary argues that (...) the harnessing of stochasticity was also involved in the evolution of the faculty of choice in organisms. (shrink)

Plato's Sophist begins with an attempt to arrive by division at a definition of a Sophist. In the course of the attempt six different descriptions are discussed and the results summarized at 231 c-e. A seventh and final account may be said to occupy the whole of the rest of the dialogue, including the long digression on negative statements. The first five divisions characterize with a considerable amount of satire different types of sophist, or more probably different aspects of the (...) sophistic art. The sixth division is very different. To quote Cornford's words, ‘satire is dropped. The tone is serious and sympathetic, towards the close it becomes eloquent’. (shrink)

In his introduction to this extraordinarily important and useful volume, Herman Geertman (G.) points out that the editions of the Liber Pontificalis produced around a century ago by Theodor Mommsen and Louis Duchesne made the Liber more an instrument, than an object, of research. For some years an international group of scholars under the leadership of Girolamo Arnaldi, François Bougard, Paolo Delogu, and G. himself, have been conducting a collaborative project on “The Liber Pontificalis as Source for the History and (...) Material Culture of Late Antiquity and the Early Middle Ages: A Collective Research Project on the Biographies from 314 to 891.” This book arises out of that project. But the present study, reflecting in particular G.'s interests, does not confine itself to “history” and “material culture.” Although the volume contains many valuable contributions on these important subjects, it also emphasizes the nature of the text of the Liber Pontificalis, the intentions of its redactors, and the accessibility of the text in terms of its language, contents, and conceptual underpinnings. G. notes that the project and the book also attempt a systematic updating of Duchesne's historical and archaeological material. The volume under review contains excellent papers that do indeed update DUCHESNE, but it cannot be said that this volume is “systematic” if by that word one understands comprehensive and exhaustive. I am not, be it emphasized, criticizing G. and his collaborators for failing to accomplish the impossible. It is important to say, however, that G.'s approach makes the Liber Pontificalis once again an object as well as an instrument of research. (shrink)

From a careful and persuasive analysis of Sophocles' debt in the Ajax to Homer's picture of Hector and Andromache's farewell in Iliad 6, P. E. Easterling concludes that in the Ajax ‘we have the paradox of an author's distinctive originality finding expression through his reading of another's work’. In what follows I wish to show that the validity of this statement extends to an aspect of the play which is touched upon by Easterling , but which I would like to (...) single out for special attention: the preoccupation with the problem of what constitutes noble action, or, in the play's own terminology, what is the nature of εγένεια. (shrink)

The philosophy of mind is intimately connected with the philosophy of action. Therefore, concepts like free will, motivation, emotions (especially positive emotions), and also the ethical issues related to these concepts are of abiding interest. However, the concepts of consciousness and free will are usually discussed solely in linguistic, ideational and cognitive (i.e. "left brain") terms. Admittedly, consciousness requires language and the left-brain, but the aphasic right brain is equally conscious; however, what it "hears" are more likely to be music (...) and emotions. Joy can be as conscious as the conscious motivation produced by the left-brain reading a sign that says, "Danger mines!!" However, look in the index of a Western textbook of psychology, psychiatry or philosophy for positive emotions located in the limbic system. Notice how discussion of positive spiritual/emotional issues in consciousness and motivation are scrupulously ignored. For example, the popular notions of "love" being either Eros (raw, amoral instinct) or agape (noble, non-specific valuing of all other people) miss the motivational forest for the trees. Neither Eros (hypothalamic) nor agape (cortical) has a fraction of the power to relieve stress as attachment (limbic love), yet until the 1950s attachment was neither appreciated nor discussed by academic minds. This paper will point out that the prosocial, "spiritual" positive emotions like hope, faith, forgiveness, joy, compassion and gratitude are extremely important in the relief of stress and in regulation of the neuroendocrine system, protecting us against stress. The experimental work reviewed by Antonio Damasio and Barbara Fredrickson, and the clinical example of Alcoholics Anonymous, will be used to illustrate these points. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Being after Rousseau: Philosophy and Culture in QuestionG. Felicitas MunzelRichard L. Velkley. Being after Rousseau: Philosophy and Culture in Question. Chicago: University of Chicago Press, 2002. Pp. x + 192. Cloth, $40.00. Paper, $18.00.In this collection of essays Velkley realizes a dual achievement: a penetrating scholarly analysis of a familiar topic, modern philosophy's on-going criticism of rational Enlightenment as a "project aiming at progressive rational mastery of nature (...) and the human situation" (60, 3), and an exemplary presentation of philosophizing as a self-reflexive activity in which the "know thyself" is posed to philosophy itself. The focus is on the German Idealist tradition, taking its origins from Rousseau and Kant to "reform, not simply to reject," but still to "overcome earlier modern accounts of scientific reason as abstract, mechanistic, and narrow, and as failing to do justice to the concrete wholeness or richness of nature and human experience, thus impoverishing our conceptions of morality, political life, and human aspirations toward the noble, the sacred, and the beautiful" (93). Velkley's scholarly interpretation identifies Rousseau as the pivotal figure who is the source both of the modern philosophical effort to achieve "human wholeness" by recovering an "original prediscursive or prerational unity" (an account that is the further source of the distinction between culture and civilization [12]) and of the "bifurcation in the ways to reach such wholeness," the ways of "citizenship" and "natural freedom" (13-14). The essays argue for an "important connection between Rousseau and Heidegger, through Kant and Schelling" (6). [End Page 345]While other thinkers are treated (for example, Pufendorf and Nietzsche), the essays primarily examine the writings of these four thinkers to elucidate "the persistence of a set of problems and a way of questioning" particular to modern philosophy (8).Velkley points out that Rousseau's critique of modern rationality is far more subtle than it is usually read. Granted, "through its introduction of self-reflectiveness into the previously 'innocent' and prereflective human situation," reason is perceived as the "true origin" and not the means for overcoming human ills (53). However, the "prereflective origin is nowhere to be found," it is an "imaginative construction," and it is a "mistake to take at face value any apparent assertion that natural man was merely an animal with only instinct and sensation" (37, 41). Because of his distinctively human awareness of time, natural man, "far from being mere animal," is "the only being whose openness to being exposes him to the nonbeing of death" (48). In short, "some 'bondage' to reason" is inescapable and "Rousseau's various plans for the reform of politics, education, the family, and the philosophical life" should be read as "ways of making the most of that bondage" (33).In the case of Kant, Velkley's emphasis is on the critical effort to resolve the dialectic, to correct the rational self-ignorance "so that the striving of reason for totality will not turn into a nihilistic rejection of reason" (112); or put another way, Rousseau inspires Kant's quid juris question, the issue of the "justification of reason as a whole," specifically the legitimacy of the categories (50-61, 101). Schelling, together with Kant's other Idealist successors, seeks a "greater unity, integration, wholeness, and concreteness than Kant provides" (113). The two main aspects of Schelling's project that Velkley discusses are (1) the discovery of the true human self in nature, the "hidden infinite unconscious self beneath the apparent finite conscious self," a "self whose objectification by the finite categories of discursive reason is quite impossible" and which thus discloses an "infinite contradiction" (115); and (2) the affirmation of the error of earlier philosophizing as belonging "essentially to philosophical inquiry" and being the very "precondition for finding truth" (125). From the philosophical attempt to correct reason's fundamental error, to its reading of "being in error" as an ineliminable step in the historical progress of reason and philosophy, Velkley turns to Heidegger's effort to step behind traditional metaphysics altogether and to move "forward into a new thinking beyond metaphysics" (142), from speech about Being to language as a power of disclosure of Being that overpowers the... (shrink)

When Aristotle limits the manifestation of true courage to the military context only, his primary target is an overly inclusive conception of courage presented by Plato in the Laches. At the same time, Aristotle explicitly tries to demarcate his ideal of genuine courage from the paradigmatic examples of courageous actions derived from the Homeric epics. It remains questionable, though, whether Aristotle is truly earnest in his efforts to distance himself from Homer. It will be argued that Aristotle's attempt to associate (...) with Homer the two forms of specious courage—courage of the citizen troops and spirit-caused courage—fails to provide sufficient criteria for the demarcation in question. All the essential elements of the Aristotelian account of courage, such as a voluntary choice, a noble goal, and a thumos-driven reaction guided by reason are exemplified by a number of Homeric characters as well. It is thus likely that the philosopher's account of courage largely incorporates the poetic tradition at a new level, rather than supersedes it. (shrink)

The latter half of the eighteenth century saw radical changes in the way nature - both external and human nature - was perceived. It is these new perceptions, these new images of the 'the natural' that this book examines: new appreciations of the 'sublime' wildness of landscape; new revelations by the life sciences of natural creative fecundity; new assertions of the innocence of 'natural man', as illustrated by the noble savage, the contented peasant, the happy family; a new sense (...) of harmony between man and nature, reflected in changing moral, psychological, economic, and religious attitudes. Professor Charlton concentrates on French examples, for in France the contrast between old and new views was particularly vivid; but there are also numerous comparisons with England and other European countries, making this a major study in the cultural history of Europe at an especially crucial time for the formation of many of our modem assumptions about man and nature. (shrink)

The basis of the Periodic Table is discussed. Electronic configuration recurs in only 21 out of the 32 groups. A better basis is derived by considering the highest classical valency (v) exhibited by an element and a new measure, the highest valency in carbonyl compounds (v*). This leads to a table based on the number of outer electrons possessed by an atom (N) and the number of electrons required for it to achieve an inert (noble) gas configuration (N*). Periodicity (...) of these is nearly complete. The new basis helps to settle the question of the best form of table and related issues. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Zen Pathways: An Introduction to the Philosophy and Practice of Zen Buddhism (禅道の千路) by Bret W. Davis (review)Steve G. LoftsBret W. Davis, Zen Pathways: An Introduction to the Philosophy and Practice of Zen Buddhism (禅道の千路)There is no shortage of books on Zen from almost every imaginable angle. And so, what makes Zen Pathways: An Introduction to the Philosophy and Practice of Zen Buddhism (禅道の千路) by Bret W. Davis unique (...) enough to take up and read, and even re-read? And who should read it? The answers to these questions depend on who you are and what you are looking for. If you are simply curious about what Zen philosophy and practice is or is not, a student, a professor looking for a textbook on Zen Buddhism for your course, or a practitioner seeking to deepen your understanding of what it is that you are practicing, then you will almost certainly enjoy and profit greatly from this book. Davis brings to the page over thirty years of active engagement with Zen Buddhism as a practitioner, teacher of philosophy and Zen Buddhism, and scholar. Davis provides his reader with an accessible, comprehensive, and well-documented introduction to the teachings and practices of Zen Buddhism. What makes this introduction stand out and be particularly effective is that Davis provides us with a scholarly and philosophical account of Zen Buddhism that is animated by his personal experience as a long-term practitioner in Japan at the Rinzai Zen monastery of Shōkokuji and as a teacher and director of the Heart of Zen Meditation Group at Loyola University Maryland. However, as the Japanese subtitle of this work, 禅道の千路, makes clear, there are “a thousand paths of the way of Zen,” and Davis is careful to show us the paths he has traveled while leaving it to the reader to find their own paths along the way.In the course of the book’s twenty-four chapters, Davis provides his reader with a clear account and philosophical interpretation of [End Page 159] the core teachings of Buddhism (the four noble truths, impermanence, the no-self doctrine, co-origination and interconnection of the one and the many, nirvana and samsara, the great death, and so on), always relating his theoretical explanations to the concrete perspective of the practice of Zen Buddhism. His account of Zen Buddhism situates it in the historical tradition of Buddhism as it was transplanted from India to China, from China to Japan, and today from Japan to other places in the world. Davis connects these teachings to the practice of Zen, providing readers with a concrete and firsthand introduction to such Zen practices as zazen (seated meditation), kinhin (walking meditation), sanzen (interviews with a teacher), koān work, and samu (meditative work), and to the Zen practice of cultivating naturalness (jinen) in and through such art forms as karate and flower arrangement (ikebana), the Japanese aesthetics of “cut-continuance” and wabi-sabi, as well as Zen-inspired gardens, painting, and music. The book also explores a number of classical and contemporary philosophical issues from the standpoint of Zen Buddhism: the problem of the one and the many, the ethical relation to the other, the problem of evil, the nature of love, freedom and determinacy, what is God, our relation to nature, and so on. Finally, the presentation of the core teachings of Zen Buddhism and the discussion of philosophical issues is undertaken in and through an intercultural and interreligious dialogue in which the similarities and dissimilarities between different cultural and faith traditions are explored and used to help illustrate the unique standpoint of Zen Buddhism. One can mention here Chapter 12 titled “Dying to Live: Zen, Pure Land Buddhism, and Christianity.” This synoptic view of Zen Buddhism is presented in an elegant, personal style that is clear, concise, and expresses a genuine passion and spirit of openness. In copious endnotes, Davis has also provided the reader with a wealth of material for further study that has been judiciously selected from good English translations of readings in the classical works as well as contemporary scholarship. Finally, with an eye to the use of this text in a classroom or in study groups, Davis has... (shrink)

Before proceeding to consider certain passages of Silius in detail I should like to enter a protest against the undue disparagement which has been meted out to this poet. The letter of Pliny , containing reflexions suggested by the voluntary death by which with stoical fortitude he sought release from the agony of an incurable tumour, presents to us a character which if not great was attractive; the character of a wealthy and kindly noble, who had made no enemies; (...) one whose house was the resort of men of letters; a devotee of poetry, who worshipped Vergil with almost religious veneration; a lover of the beautiful, who found his pleasure according to the accepted Roman fashion in amassing works of art and tasteful country mansions. Pliny's terse criticism of his poem ‘scribebat carmina maiore cura quam ingenio’ is more just than that of modern critics. Though Silius is not a great poet, a poet he is, with merits distinctly his own. His Punica is hardly an epic proper, but is rather a chronicle in verse: as such its author displays considerable skill in the clearness with which he marshals the mass of events, and in the realistic force of his descriptions, especially that of the plague , and those of the numerous battles, and particularly of the sea-fights ; and in the elaboration of geographical detail, where the vividness of the topographical presentation shows a well-trained eye and no common literary power The numerous episodes which enliven the poem, such as the legend of Pyrene , the killing of the monster serpent , the pretty description of Pan , are executed with much imaginative fancy which recalls the manner of Ovid's Metamorphoses. Again there is a dignity and sustained elevation of language which results not unfrequently in vigorous, well-turned phrases of no ordinary merit. Such are the expression for an echo xiv. 365 ‘clamat scopulis clamoris imago,’ or for breaking through the ranks of the treacherous Greeks xvii. 425 ‘periuria Graia resignat,’ or again the fine line describing the sobbing sound made by water rushing into a wrecked ship's hull and out again xiv. 550 ‘mox sua ponto | singultante anima propulsa refunditur unda.’. (shrink)

The purpose of this article is both to examine Plato's own use of the noble lie in politics and to examine it within the context of contemporary political philosophy, a context wherein at least three different assessments of the noble lie are possible. First I will consider the strengths of those (e.g. Karl Popper) who see the noble lie as part of, or at least leading to, totalitarian politics. Second I will also consider the degree to which (...) contemporary (Leo Straussian) defenders of Plato can adequately defend the noble lie. Thirdly, I will articulate and defend a third (John Rawlsian) view that mediates between the above two views, albeit in a way that finds the noble lie morally objectionable even if it is not necessarily seen as part of totalitarian political aspirations. In effect, I lean more towards the Popperian assessment of the noble lie than towards the Straussian one, even if it must be admitted that the Popperian assessment is hyperbolic. (shrink)

Utilitarianism tells us that actions are morally right and good if and to the extent that they add to human happiness or diminish human unhappiness. And—or, perhaps, therefore—it also tells us that the best action a person can perform is that which of all the possible actions open to him is the one which makes the greatest positive difference to human happiness. Moreover, as everyone will also remember, utilitarianism further tries to tell us, perhaps intending it as a corollary of (...) that first, main claim, that the motive for an action has nothing to do with its moral rightness or goodness. But even if, as utilitarians, we accepted the dubious corollary, it would not follow, as many have thought, that utilitarians have no moral interest in motives. For unless, absurdly, a utilitarian believed either that there was never more than a fortuitous connection between on the one hand what we intended to do and on the other what we did and the consequences of what we did, or that, if there were such connections, we could not know of them, he must believe, as a moralist, that the best motive a person can have for performing an action is likely to be the desire to produce the happiest result. Indeed, utilitarians ought to be morally committed, it would seem, to trying to find out as much as they can about the consequences of our actions, e.g. what connections exist, if any, between how we raise children and what sort of adults they grow up to be. (shrink)

"Alterity and Criticism: Retracing Time in Modern Literature" argues that the role of time in canonical literature underlies the experience of alterity and requires a new hermeneutic to clarify how the self emerges in literary texts. Romantic poetry from Goethe to Shelley and the modern prose tradition from Flaubert to Butor constitute different traditions but also indicate, on a textual basis, how alterity is crucial to reading, thus encouraging us to interpret literary texts in terms of the related concerns of (...) self, other and time. This volume engages in discussions of cultural semiotics and late phenomenology, and provides insights into how modern literature provides one way of assessing the possibility of World Literature for our own time. It will be of interest to students and scholars of both literature and philosophy. (shrink)